ITROPINE 100.MG CAPSULES 4’s

Composition

Each capsule contains:

• Itraconazole 100 mg
• Excipients: q.s.

Indications (Uses)

Itropine is indicated for the treatment of fungal infections caused by susceptible organisms, including:

• Vulvovaginal candidiasis
• Oral and esophageal candidiasis
• Dermatophytosis (Ringworm)
• Tinea corporis
• Tinea cruris (Jock itch)
• Tinea pedis (Athlete’s foot)
• Pityriasis (Tinea) versicolor
• Onychomycosis (Fungal nail infections)
• Aspergillosis
• Histoplasmosis
• Blastomycosis and other systemic fungal infections (as prescribed)

Note: Itraconazole is effective only against fungal infections and should not be used to treat bacterial or viral infections.

Mechanism of Action

Itraconazole inhibits fungal cytochrome P450-dependent 14-α-demethylase, blocking the synthesis of ergosterol, an essential component of the fungal cell membrane. This results in inhibition of fungal growth and cell death.

Dosage & Administration

• Adults: Dosage depends on the type and severity of the infection.
• Common dose: 100–200 mg once or twice daily, as directed by the physician.
• Take immediately after a full meal for better absorption.
• Swallow the capsule whole with water.
• Complete the full prescribed course of treatment.

Common Side Effects

• Nausea
• Vomiting
• Abdominal pain
• Indigestion
• Headache
• Dizziness
• Diarrhea
• Skin rash

Serious Adverse Effects

Seek immediate medical attention if any of the following occur:

• Severe allergic reactions
• Liver injury (yellowing of the skin or eyes, dark urine)
• Heart failure symptoms (shortness of breath, swelling of legs)
• Severe skin reactions (Stevens–Johnson syndrome)
• Persistent vomiting or severe abdominal pain

Contraindications

• Hypersensitivity to itraconazole or other azole antifungal agents
• Congestive heart failure (unless benefits outweigh risks)
• Pregnancy (except for life-threatening fungal infections)
• Concomitant use with certain medicines that may cause serious drug interactions

Warnings & Precautions

• Monitor liver function during prolonged treatment.
• Use cautiously in patients with liver or kidney impairment.
• Inform your doctor if you have heart disease.
• Avoid use during pregnancy unless clearly indicated.
• Breastfeeding mothers should consult a physician before use.

Drug Interactions

Itraconazole has numerous clinically significant interactions and may interact with:

• Statins (e.g., simvastatin, lovastatin)
• Warfarin
• Digoxin
• Certain antiarrhythmics
• Benzodiazepines (e.g., midazolam, triazolam)
• Rifampicin and rifabutin
• Carbamazepine and phenytoin
• Proton pump inhibitors and antacids (may reduce itraconazole absorption)

Storage

• Store below 30°C in a cool, dry place.
• Protect from moisture, heat, and direct sunlight.
• Keep out of the reach of children.