NAPPIN 20/500 MG TABLETS 14’s

Description

Composition:NAPPIN Tablets 500 mg + 20 mg

(Naproxen 500 mg + Esomeprazole 20 mg)

Generic Name:

• Naproxen 500 mg
• Esomeprazole 20 mg

Dosage Form:

• Delayed-release tablets
• Pack size: 14 tablets

Therapeutic Class:

• Non-Steroidal Anti-Inflammatory Drug (NSAID) + Proton Pump Inhibitor (PPI)

Each tablet contains:

• Naproxen 500 mg
• Esomeprazole Magnesium (equivalent to Esomeprazole) 20 mg

Indications (Uses):

• Osteoarthritis
• Rheumatoid arthritis
• Ankylosing spondylitis
• Acute musculoskeletal pain
• Back pain
• Tendonitis and bursitis
• Dental pain
• Dysmenorrhea (painful menstruation)
• Patients requiring long-term NSAID therapy with protection against gastric ulcers

Mechanism of Action:

• Naproxen reduces pain, inflammation, and fever by inhibiting cyclooxygenase (COX-1 and COX-2), thereby decreasing prostaglandin production.
• Esomeprazole suppresses gastric acid secretion by inhibiting the gastric proton pump (H⁺/K⁺-ATPase), helping protect the stomach from NSAID-induced ulcers.

Dosage & Administration:

• Adults: One tablet twice daily, or as directed by the physician.
• Take at least 30 minutes before meals.
• Swallow the tablet whole with water.
• Do not crush, split, or chew the tablet.

Common Side Effects:

• Heartburn
• Nausea
• Abdominal pain
• Indigestion
• Diarrhea or constipation
• Headache
• Dizziness
• Flatulence

Serious Adverse Effects (Seek Medical Attention):

• Gastrointestinal bleeding or black stools
• Severe allergic reactions
• Chest pain or shortness of breath
• Kidney problems (reduced urine output)
• Liver dysfunction (jaundice)
• Severe skin reactions

Contraindications:

• Hypersensitivity to naproxen, esomeprazole, aspirin, or other NSAIDs
• Active peptic ulcer or gastrointestinal bleeding
• Severe liver failure
• Severe kidney impairment
• History of NSAID-induced asthma or allergic reactions
• Use during coronary artery bypass graft (CABG) surgery

Warnings & Precautions:

• Use the lowest effective dose for the shortest duration.
• Use cautiously in elderly patients.
• Monitor kidney function, liver function, and blood pressure during prolonged therapy.
• Avoid alcohol, as it increases the risk of stomach bleeding.
• Inform your physician if you have heart disease, hypertension, asthma, or a history of ulcers.
• Use during pregnancy or breastfeeding only if prescribed by a healthcare professional.

Drug Interactions:
May interact with:

• Warfarin and other anticoagulants
• Aspirin and other NSAIDs
• Corticosteroids
• SSRIs (e.g., sertraline, fluoxetine)
• Diuretics
• ACE inhibitors/ARBs
• Methotrexate
• Lithium
• Digoxin
• Clopidogrel

Storage:

• Store below 30°C in a dry place.
• Protect from moisture and direct sunlight.
• Keep out of the reach of children.